HORDB

ID: hor005227
Uniprot ID: P01259
Protein name: Calcitonin
Gene name: CALCA
Organism: Sus scrofa (Pig)
Family: Calcitonin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Mechanism: NA
Cross BBB: NA
Target: RAMP1
Target Unid: Q867C0
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01259-F1.pdb

hor005227_AF2.pdb

hor005227_ESM.pdb

Mass:	416015	Formula:	C159H233N45O46S3
Absent amino acids:	DIKQ	Common amino acids:	NS
pI:	8.23	Basic residues:	3
Polar residues:	16	Hydrophobic residues:	9
Hydrophobicity:	-25.63	Boman Index:	-4714
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	868.13	Extinction Coefficient cystines:	7115
Absorbance 280nm:	229.52